The cause of the discrepancy between pathologic diagnosis and clinical diagnosi
PUBLISHED: 2015-11-30  504 total views, 1 today

Wen-jun Chen, Geng Song, Nian-fei Wang, Xiu-wei Wu, Ze-qing Li, Chang-zhen Li, Zhen-dong Chen

Medical Oncology, Second Affiliated Hospital of Anhui Medical University


Objective:To explore the influencing factors on accuracy and consistency of clinical and pathological diagnosis of lymphoma, and its effect on treatment. Method: From January 2014 to December 2014 in the Second Affiliated Hospital of Anhui Medical University, 115 hospitalized patients with lymphoma were included in this study. The accuracy and absence of pathological diagnosis, discrepancy between clinicaland pathological diagnosis and the prognosis of all the patients were assessed. Result: Among 115 lymphoma patients, 2 had no pathological diagnosis, 59 had nodal lymphoma including 54 extranodal lymphoma and 50 had non-Hodgkin lymphoma diffuse large B-cell lymphoma, 60 non-diffuse large B-cell lymphoma. The diagnostic reliability of nodal lymphoma and diffuse large B cell lymphoma was higher than it in extranodal lymphoma and non- diffuse large-B cell lymphoma respectively. Reliability of pathological diagnosis maybe affected by pathological diagnostic methods. 12 cases had inconsistency in clinical and pathological diagnosis (10.4%), mainly related to the location and different pathological diagnostic methods. Followed by 6 months in 14 patients (12 with inconsistency diagnosis and 2 without pathology diagnosis), 5 achieved CR, 8 achieved PR, and 1 achieved SD post clinical therapy. Conclusion: The location and pathological diagnostic methods appear to play an important role in the inconsistent results of clinical and pathological diagnosis. Discrete treatment could be applied when pathological diagnosis is absent or inconsistent with clinical diagnosis. 


Key Words: lymphoma  nodal and extranodal lymphoma

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